Whether you're looking to gain muscle, lose fat, drop weight, or boost endurance, chances are there's a supplement out there for you.

But one that needs a bit more conversation around it is called Capsimax—one of the cleanest, most-effective, and 100% natural fat burning products you can get your hands on.

Want to know more about it, what it does, and where you can find it?

Keep reading, and we will outline everything you need to know about Capsimax and why if it's not already, it should be part of your daily supplement routine.

What is Capsimax?

Capsimax is one of the latest and greatest additions to the fat-burning world.

It is a concentrated, highly active, natural extract from red chili peppers that provides all the heat and benefits of capsaicin, without the burn that travels all the way down your esophagus and leaves your stomach with that warm, tingly feeling.

The capsaicinoids in Capsimax help to support energy production by boosting metabolism, mobilizing fats for energy production, and generating heat in the body to crank up internal temperature and maximize calorie burn.

It's a completely safe, non-stimulant dietary ingredient available in many products worldwide that support healthy weight management and proper nutrition.

Capsaicinoids and Capsaicin

Capsaicinoids (CAPs) are the major pungent, naturally occurring active compounds found in chili peppers that possess quite a number of biological and physiological activities, some of which include managing inflammation, decreasing oxidative stress, cardio-protective, anti-arthritic, and much more 1.

Capsaicin, specifically, is one of the four main alkaloids derived from the fruit of the Capsicum plant that is responsible for giving chili peppers their inherent spiciness.

Along with capsaicin, there is dihydrocapsaicin, which together comprises about 90% of capsaicinoids in chili peppers, but there are also nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin 2.

There's a substantial amount of research available showing that CAPs are highly beneficial as part of a weight management program.

They elicit favorable effects for weight loss, lipolysis (fat breakdown), and stimulating thermogenesis and energy expenditure by activating receptors in both white and brown fat cells 1.

When consumed, capsaicinoids are not only able to turn up core body temperature, but they cause a reaction in the body that is similar to that of exercise.

Capsaicin stimulates an increase in sympathetic nervous system activity, which causes a subsequent increase in the secretion of the catecholamines epinephrine and norepinephrine 3.

High levels of circulating catecholamines are one of the main factors behind increased fat mobilization and stimulation of lipolysis 4.

Keep reading to find out more on how exactly Capsimax works and why it can be incredibly beneficial to your fat loss stack.

Capsimax's OmniBeadTM Technology

This aspect of Capsimax is unique and a huge selling point.

If you've ever eaten any amount of cayenne pepper, you know that it can be incredibly irritating to the esophagus and even your stomach. But with Capsimax's OmniBead technology, you can leave the worry and pain behind.

OmniBead™ beadlets encapsulate capsaicin in a time-release coating, providing you with sufficient levels of capsaicinoids without the oral and gastric burning sensation associated with consuming raw chili peppers.

The outer coating of Capsimax can withstand the highly acidic environment of the stomach, which means it can pass through and into the lower parts of the intestinal tract, where it is completely broken down and absorbed.

How Does It Work?

Compared with ingredients you'll find in traditional fat burners, Capsimax offers a stim-free alternative to boosting fat loss and enhancing your workout performance. But that's not the only thing it does. It's also known as a potent pain relief agent.

Pain Relief

Most of the studies on capsaicin have been linked to its action on the transient receptor vanilloid 1 (TRPV1) to which capsaicin binds.

TRPV1 is widely expressed in sensory receptors, but aside from being primarily concentrated in nociceptive neurons (pain receptors), TRPV1 is also found in other tissues like the brain, bladder, kidneys, intestines, epidermis (skin), liver, and immune cells 2.

TRPV1 contains a heat-sensitive subunit that is responsible for the burning sensation caused by capsaicin ingestion.

Binding of capsaicin to TRPV1 increases intracellular calcium levels, which triggers the release of compounds like substance P and the calcium gene-related peptide (CGRP).

This contact between capsaicin and sensory neurons elicits pain, inflammation, and a localized heat sensation 2.

When applied topically, capsaicin functions as an analgesic (pain reliever) by desensitizing sensory neurons, thus relieving pain.

So, if you ever get an injury while training, topical capsaicin application may help to reduce some of the pain! But keep in mind that if it's an open wound, it may not be so pleasant.

Lipolysis

Concerning fat burning, the mechanism of action is a bit different and slightly less understood.

Studies show that capsaicin consumption can influence metabolic rate and regulating hunger and satiety, blood metabolites, and catecholamine release 1.

The thermogenic effect elicited by capsaicinoids is mediated, at least in part, by a capsaicinoids-sensitive structure located in the rostral ventrolateral medulla 1, an area of the brain that handles basal and reflex control of sympathetic activity.

Capsaicinoids may also stimulate vasodilation, which may have an indirect effect on thermogenesis, as heat loss may boost metabolic rate.

Another study suggests that red pepper's effect on energy balance results from a combination of metabolic and sensory inputs.

Its effect on appetite suppression and lipolysis are mediated in part by gene expression involved in the lipid catabolic pathway, including those involved in thermogenesis 1; the effect may be due to vanilloid receptor subtype 1 (VR1) binding capsaicin, but research is still needed in this area.

Catecholamines

Another mechanism of action is capsaicinoids effect on circulating catecholamine levels; PSA: it's a little science-y, but you'll understand the point.

Studies suggest that capsaicinoids are an agonist (something that causes a reaction) of the transient receptor potential vanilloid subfamily member 1 (TRPV1). This receptor releases substance P, which in turn activates the postsynaptic receptor of substance P, neurokinin-1.

Activation of neurokin-1 activates the sympathetic nervous system, which causes the release of epinephrine (EPI) and norepinephrine (NE) from the adrenal glands.

Epinephrine and norepinephrine both interact with a hormone called hormone-sensitive lipase, which may cause a direct increase in triglyceride degradation and a subsequent increase in circulating free fatty acids (FFA) and glycerol that result from the breakdown of triglycerides 5.

But what's interesting is that studies show capsaicinoids may not actually cause increased levels of NE and EPI, but they do increase plasma FFA and glycerol serum concentrations.

Here's what else capsaicinoids do on top of helping fat metabolism 2:

  • Act as an antioxidant to protect cells from free-radical damage
  • Enhance energy metabolism
  • Suppress fat accumulation
  • Reduce inflammation

And as a potent thermogenic agent, capsaicinoids can turn up the heat! When free fatty acids are released during lipolysis, they signal a protein found in brown adipose tissue (BAT) known as uncoupling protein-1 (UCP-1), which converts adenosine triphosphate (ATP), the body's main source of energy, into heat. As a result, we experience a boost in core temperature.

The Proof

Body Composition and Lipolysis

There's ample evidence to suggest that capsaicinoids help to mobilize fat and decrease fat stores.

They have found evidence that subjects taking capsaicin supplements for four months had an increase in fat utilization and decreased fat stores, which was measured through a process called lipid oxidation 6.

But with respect to capsaicin supplements, Capsimax, specifically, is highly effective in mobilizing free fatty acids for energy use.

In one specific study, circulating blood levels of free fatty acids were measured in 20 men and women.

Results showed that FFA were higher for two hours after taking Capsimax containing 2 mg of capsaicinoids with no apparent side effects 5.

Interestingly though, capsaicinoids may be more effective for people who are overweight, as FFA mobilization increases in people with a higher BMI (> 25) 7.

Thermogenesis and Metabolism

As with its effect on lipolysis, there's plenty of evidence to go around suggesting that capsaicin can rev metabolism through its thermogenic property.

One study looked at the effects of red pepper on diet-induced thermogenesis and fat oxidation.

Subjects were given meals in one of four conditions: a high-fat meal, a high-fat meal with red-pepper (10 g), a high carbohydrate meal, or a high carbohydrate meal with red-pepper 8.

Results showed that diet-induced thermogenesis was significantly higher after the high carb meals than after the high-fat meals, and lipid oxidation was higher after the high-fat meal.

Another study found that just seven days of supplementation with a bioactive fat burner containing capsaicin, tyrosine, green tea extract, and caffeine increased 4-hour thermogenesis by 90 kJ more than the placebo, and the effect was maintained after eight weeks and was accompanied by a mild reduction in fat mass 9.

Where to Buy Capsimax

While Capsimax is widely available as a single supplement, you can maximize the benefits you receive by combining it with other fat-burning ingredients, which is precisely what Burn Lab Pro does.

In Burn Lab Pro, you're getting five unique ingredients that synergistically work to enhance your performance and help you achieve your fat loss goals.

  • ForsLean—a researched-based Coleus forskohlii extract that helps fat breakdown, fat burning, muscle preservation, and muscle gain
  • HMB—promotes maximum muscle growth and accelerates recovery
  • NutriGenesis GTF Chromium—controls appetite, fuels muscle, stabilizes energy, and enhances insulin function to fight insulin resistance
  • BioPerine—metabolism-boosting bio-enhancer to increase nutrient absorption and utilization

When Should I Take Capsimax?

Whether you're looking to enhance your performance on a workout day or boost fat loss during recovery, Capsimax is best taken first thing in the morning on an empty stomach for non-training days or 30-minutes before training to maximize absorption and accelerate your results.

When used before training, Capsimax works to rev metabolism, increase body temperature, and enhance calorie burn for a more effective workout. With Burn Lab Pro, take two capsules 30 minutes before exercise and see what a difference it can make.

Research also shows positive results when capsaicin is taken before a meal. It may help reduce energy intake by up to 75 calories 1.

Capsimax Side Effects

Unlike many other weight and fat loss products, side effects aren't something you have to worry about where Capsimax is concerned. There have been no adverse effects associated with ingestion of Capsimax.

Because of the nature of Capsimax capsules and the OmniBead beadlets, ingestion seems to be well tolerated with no observed side effects related to gastric upset or discomfort 5.

Other studies show that doses of up to 10mg of CAPs were well tolerated and safe for weight management studies. This study outlined several markers to assess tolerability 10:

  • Primary markers: skin color and changes in skin, bowel movement, digestion, mouth or throat, hair color or changes in hair color, urination frequency and burning sensations, breathing, any changes in health status
  • Secondary outcomes: body weight, body mass index (BMI), blood pressure (SBP/DBP), vital signs, ECGs, clinical chemistry parameters (liver function, lung function, and kidney function), complete blood count (CBC)

Tolerability assessments and safety blood markers showed no significant changes from baseline levels, and no significant serious adverse events were reported throughout the study.

References

  1. J Rogers, SL Urbina, LW Taylor, et al. Capsaicinoids supplementation decreases percent body fat and fat mass: adjustment using covariates in a post hoc analysis. BMC Obes. 2018; 5: 22.
  2. L Reyes-Escogido Mde, EG Gonzalez-Mondragon, E Vazquez-Tzompantzi. Chemical and pharmacological aspects of capsaicin. Molecules. 2011; 16(2): 1253-1270.
  3. T Watanabe, T Kawada, M Yamamoto, K Iwai. Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun. 1987; 142(1): 259-264.
  4. J Deshpande, S Jeyakodi, V Juturu. Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study. J Toxicol. 2016; 2016: 6584649.
  5. RJ Bloomer, RE Canale, S Shastri, S Suvarnapathki. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. Lipids Health Dis. 2010; 9: 72.
  6. MP Lejeune, EM Kovacs, MS Westerterp-Plantenga. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr. 2003; 90(3): 651-659.
  7. N Inoue, Y Matsunaga, H Satoh, M Takahashi. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem. 2007; 71(2): 380-389.
  8. M Yoshioka, S St-Pierre, M Suzuki, A Tremblay. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr. 1998 Dec; 80(6): 503-10.
  9. A Belza, E Frandsen, J Kondrup. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond). 2007; 31(1): 121-130.
  10. J Deshpande, S Jeyakodi, V Juturu. Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study. J Toxicol. 2016; 2016: 6584649.